people
research
publication
contact
news
links
Felipe Cortés, PhD
Full Professor in Cell Biology
Department of Cell Biology
University of Seville
Avda. Reina Mercedes nº 6
41012- Seville (Spain)
Phone. +34 954 557039
Fax. +34 954 610261
e-mail: cortes@us.es
B.S.c. University of Seville, Spain 1974.
M.S.c. University of Seville, Spain 1974.
PhD. University Autonomous of Madrid, Spain 1977.

First, his field of research was Plant Cytogenetics, mainly concerning DNA replication and cell cycle. Sister chromatid exchanges and chromosome aberrations were the endpoints of choice. After a six-year stay doing research at the Spanish Research Council (Madrid), in 1980 he moves to the University of Seville, where he set up his own research team with an interest on DNA damage induced by different environmental mutagens as well as the cell mechanisms that deal with such a damage. While up to 1985 plant cells had been almost exclusively the material employed, that year he moved to the University of Uppsala (Sweden), and later on to the University of San Francisco in California (USA) to get acquainted with in vitro cell culture methodologies for mammalian and human cells.

He´s the Director of the research team Cell Culture and Radiobiology which laboratory at the Faculty of Biology of Seville (Spain) is committed to a continuous updating of goals and methodologies as a result of contacts with scientists wordwide as well as collaborations and exchanges with other laboratories. So far their major areas of research using cultured mammalian cells have been the following: radiation protection studies carried out within the framework of European Union Coordinated Projects, mechanisms involved in chromosomal aberrations and sister chromatid exchange (for the detection of DNA damage), possible participation of different nuclear enzymes (mainly DNA topoisomerases I and II) in the repair of damaged DNA, genotoxic damage in birds of the Doñana National Park (southwest Spain) in the aftermath of the mining toxic waste spill to Guadiamar river and, among others, assays of andalusian and latin American plant extracts as to their possible antitumor activity. Dr F.Cortés is the autor of 3 textbooks on Plant Histology, and is a member of the Mutation Research (Elsevier) Editorial Board.

.:: PUBLICATIONS FROM THE LAST FEW YEARS ::.
 
  click here for all publications

Cantero G, Campanella C, Mateos S, Cortes F.
Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin.
Mutagenesis. 2006 Sep;21(5):321-5. Epub 2006 Sep 1.
PMID: 16950806 [PubMed - indexed for MEDLINE] ------

Cantero G, Pastor N, Mateos S, Campanella C, Cortes F.
Cisplatin-induced endoreduplication in CHO cells: DNA damage and inhibition of topoisomerase II.
Mutat Res. 2006 Jul 25;599(1-2):160-6. Epub 2006 Mar 30.
PMID: 16574165 [PubMed - indexed for MEDLINE] ------

Mateos S, Hajji N, Pastor N, Cortes F.
Modulation of radiation response by inhibiting topoisomerase II catalytic activity.
Mutat Res. 2006 Jul 25;599(1-2):105-15. Epub 2006 Mar 30.
PMID: 16574164 [PubMed - indexed for MEDLINE] ------

Cantero G, Mateos S, Pastor N, Cortes F.
Halogen substitution of DNA protects from poisoning of topoisomerase II that results in DNA double-strand breaks.
DNA Repair (Amst). 2006 Jun 10;5(6):667-74. Epub 2006 Jan 10.
PMID: 16406738 [PubMed - indexed for MEDLINE] ------

Lopez-Lazaro M, Pastor N, Azrak SS, Ayuso MJ, Cortes F, Austin CA.
Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.
Leuk Res. 2006 Jul;30(7):895-8. Epub 2006 Jan 4.
PMID: 16387358 [PubMed - in process] ------

Lopez-Lazaro M, Pastor N, Azrak SS, Ayuso MJ, Austin CA, Cortes F.
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.
J Nat Prod. 2005 Nov;68(11):1642-5.
PMID: 16309315 [PubMed - indexed for MEDLINE]

Cortés Benavides, Felipe
La naturaleza del ADN. Determina una correcta segregación de los cromosomas en la mitosis
Investigación y Ciencia, Junio 2005, pag 35-36. ------

Mateos S, Domínguez I, Pastor N, Cantero G, Cortes F.
The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells.
Mutat Res. 2005 Oct 15;578(1-2):33-42. Epub 2005 Mar 23.
PMID: 16202795 [PubMed - indexed for MEDLINE]] ------

Hajji N, Mateos S, Pastor N, Dominguez I, Cortes F.
Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor.
Mutat Res. 2005 May 2;583(1):26-35.
PMID: 15866463 [PubMed - indexed for MEDLINE] ------

Pastor N, Cantero G, Campanella C, Cortes F.
Endoreduplication induced in cultured Chinese hamster cells by different anti-topoisomerase II chemicals. Evidence for the essential contribution of the enzyme to chromosome segregation.
Mutat Res. 2005 Apr 4;582(1-2):11-9. Epub 2005 Jan 24.
PMID: 15781205 [PubMed - indexed for MEDLINE] ------

Cortes F, Mateos S, Pastor N, Dominguez I.
Toward a comprehensive model for induced endoreduplication.
Life Sci. 2004 Nov 26;76(2):121-35. Review.
PMID: 15519359 [PubMed - indexed for MEDLINE] ------

Hajji N, Pastor N, Mateos S, Dominguez I, Cortes F.
DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.
Mutat Res. 2003 Sep 29;530(1-2):35-46.
PMID: 14563529 [PubMed - indexed for MEDLINE] ------

Cortes F, Pastor N, Mateos S, Dominguez I.
The nature of DNA plays a role in chromosome segregation: endoreduplication in halogen-substituted chromosomes.
DNA Repair (Amst). 2003 Jun 11;2(6):719-26.
PMID: 12767350 [PubMed - indexed for MEDLINE] ------

Pastor N, Jose Flores M, Dominguez I, Mateos S, Cortes F.
High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor.
Mutat Res. 2002 Apr 26;516(1-2):113-20.
PMID: 11943617 [PubMed - indexed for MEDLINE] ------

Pastor N, Dominguez I, Mateos S, Cortes F.
A comparative study of genotoxic effects of anti-topoisomerase II drugs ICRF-193 and bufalin in Chinese hamster ovary cells.
Mutat Res. 2002 Mar 25;515(1-2):171-80.
PMID: 11909765 [PubMed - indexed for MEDLINE] ------

Dominguez I, Pastor N, Mateos S, Cortes F.
Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.
Mutat Res. 2001 Oct 18;497(1-2):71-9.
PMID: 11525909 [PubMed - indexed for MEDLINE] ------

Dominguez I, Mateos S, Cortes F.
Related Articles, Links
Yield of SCEs and translocations produced by 3 aminobenzamide in cultured Chinese hamster cells.
Mutat Res. 2000 Mar 14;448(1):29-34.
PMID: 10751620 [PubMed - indexed for MEDLINE] ------

Department of Cell Biology - University of Seville Avda. Reina Mercedes 6, 41012 SEVILLE (Spain)
 diseño: cristinameneses.com