Scope
This line of work focuses on the development of novel description techniques for assessing the progression of emphysema from HRCT images of COPD (Chronic Obstructive Pulmonary Disease) patients.
In the pursuit for better understanding COPD, we are working on a pattern recoginition scheme that allows for computing the relative area of six emphysema classes usually encountered in the COPD lung. Our approach is simpler than texture analysis techniques while obtaining similar results. Thus the current gap between clinical-practice densitometry and impractical time-consuming texture analysis can be abridged by the use of our simpler descriptor: local intensity distributions.
Ultimately, our technique is susceptible of being incorporated in clinical practice. COPD patients can benefitt from fully-automatic tissue percentage computations, which is much richer a description of the pulmonary condition than current densitometric approaches and can finely assess the response to therapy or the correlation with genetics.
Collaborations
Applied Chest Imaging Lab – Division of Pulmonology and Critical Care , Brigham and Women’s Hospital – Harvard Medical School. BOSTON, USA
Images
Publications
- Lo, P., van Ginneken, B., Reinhardt, J.M., Yavarna, T., Jong., P.A., Irving, B., Fetita, C., Ortner, M., Pinho, R., Sijbers, Feuerstein, M., Fabijanska, A., Bauer, C., Beichel, R., Mendoza, C.S., Wiemker, R., Lee, J., Reeves A.P., Born, S., Weinheimer, O., van Rikxoort, E.M, Tschirren, J., Mori, K., Odry, B., Naidich, D.P., Hartmann, I., Hoffman, E.A., Prokop, M., Pedersen, J.H., de Bruijne, M. Extraction of Airways from CT (EXACT’09) IEEE Transactions on Medical Imaging (in press).
- San Jose Estepar, R., Mendoza, C.S., Ross, J.C., Diaz, A., Lynch, D.A., Crapo, J., Silverman, E.K., Washko, G.R. Quantifying Patterns Of Emphysema By Local Density Histogram In Chest CT Scans. (2012) International Conference of the American Thoracic Society, 18-23 May 2012 (in press)
- Castaldi, P., San Jose Estepar, R., Mendoza, C.S., Cho, M.H., Crapo, J., Lynch, D.A., Beaty, T., Washko, G.R., Silverman, E.K. Genome-Wide Association Study For Local Histogram Emphysema Patterns Identifies Loci Near CHRNA3/5 And MMP12/MMP3/P (2012) International Conference of the American Thoracic Society, 18-23 May 2012 (in press)
- Mendoza, C.S., Washko G.R., Ross, J.C., Díaz, A.A., Lynch, D.A., Crapo, J.D., Silverman, E.K., Acha, B., Serrano, C., San Jose Estepar, R. Emphysema quantification in a multi-scanner HRCT cohort using local intensity distributions (2012) Proceedings – International Symposium on Biomedical Imaging, 2-5 May 2012 (in press).
- Mendoza, C.S., Acha, B., Serrano, C. Maximal Contrast Adaptive Region Growing for CT Airway Tree Segmentation (2009) The Second International Workshop on Pulmonary Image Analysis, Sep. 20 2009
